KO mice • Phenotype the SACS KO mice using the following instruments: Rotarod, Micro CT, Grip- strenght, Open-field test. • Continue the histological analysis of the SACS KO : DRG, muscles, retina, sciatic and optic nerves. • Test different neuronal modifications. • Build capacity for therapeutic trials on the mice. KI mice Establish the colony of knock-in R272C mice. • …
Scientific Research Objectives
Scientific Research Objectives for 2010/11 The objectives for the research project have been established for 2010-2011 for the following categories: • Structural studies • Cellular models and protein partners • Studies of transgenic mice • Organotypic models of hyppocampus and cerebellum • Publications/Broadcast/ Granting agencies. Structural studies • Crystal structure of other sacsin domains. • Cloning and molecular modeling of …
