ARSACS project gets grant from Italian Ministry of Health

In Research in 2017 by ARSACS

The Italian Ministry of Health will fund the project “Insight into new therapeutic preclinical strategies in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay type” presented by: Summary of the Project: “Autosomal recessive spastic-ataxia of Charlevoix-Saguenay (ARSACS) is a multisystem hereditary ataxia associated with mutations in SACS, encoding sacsin, a protein whose function is only in part understood. Mutations in SACS impair …

Complete the characterization of Sacsin Interacome and establish how it is modified in disease and by therapeutic compounds – Dr. Bernard Brais and Dr. Eric Shoubridge

In Research in 2017 by ARSACS

  Project description to come     Duration: one year Grant: $100,000 Contacts: Dr. Bernard Brais, co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital 3801 University Street Montreal, Quebec, Canada H3A 2B4 Tel:(514)-398-3334; Email: bernard.brais@mcgill.ca Dr. Eric Shoubridge, Montreal Neurological Institute and Hospital 3801 University Street Montreal, Quebec, Canada H3A 2B4 Tel: (514)-398-1997; Email: eric.shoubridge@mcgill.ca Interesting, …

Completing the first high-throughput drug screening using an ARSACS fibroblast assay – Dr. Bernard Brais and Dr. Michel Bouvier

In Research in 2017 by ARSACS

Project description to come   Duration : One year Grant: $100,000 Contacts: Dr. Bernard Brais, co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital 3801 University Street Montreal, Quebec, Canada H3A 2B4 Tel:(514)-398-3334; Email: bernard.brais@mcgill.ca             Dr.Michel Bouuvier, Institute for Research in Immunology and Cancer  (IRIC) Université de Montréal | Pavillon Marcelle-Coutu …

Integrated Structural Studies Using Electron Microscopy and Cristallopraphy – Dr Kalle Gehring

In Research in 2017 by ARSACS

Project description to come. Duration: one year Grant: $98,350 Contact: Dr. Kalle Gehring, Professor Department of Biochemistry MCGill University Francesco Bellini Life Sciences Building, 3649 promenade Sir-William-Osler, Office: Room 469; Lab: Room 473, Montreal, Quebec H3G 0B1 Tel:(514)-398-7287; Lab: (514)-398-2873/1496; Fax:(514)-398-2983; Email: kalle.gehring@mcgill.ca Interesting, right? Share with your friends & followers / Intéressant, non? Partagez avec vos amis:

Caractérisation des déficiences musculaires associées aux difficultés à la marche et aux transferts chez les patients atteints de l’ARSACS :de la cellule à la fonction- Dr Luc Hébert

In Research in 2017 by ARSACS

Caractériser les déficiences de force et de contrôle de mouvements volontaires et les limitations d’activité liées à la mobilité; 2) caractériser leurs interrelations; et 3) identifier les variables cliniques qui expliquent le mieux les limitations d’activités telle que la vitesse de marche.   Durée: un an Bourse : $73,300 Contact: Dr.Luc Hébert , Chercheur, CIRRIS, Bureau H-1702 . IRDPQ, 525 boulevard Hamel, …

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Disrupted Protein Homeostasis in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay- Dr. Paul Chapple

In Research in 2017 by ARSACS

The objectives of the research project are to: 1. Identify the proteostasis systems that are activated in sacsin null cells 2. Identify proteins that are recruited to the aggresome-like structure in sacsin null cells 3. Identify if there is evidence for disruption of proteostasis systems in human ARSACS neurons.         Duration: Second year of a three year …

Characterizing and Ameliorating Axonal Transport Defects in ARSACS Mice – Dr. Thomas Schwartz

In Research in 2017 by ARSACS

    Project description to come   Duration: one year Grant: $74,000USD Contact: Dr. Thomas L. Schwarz, Professor, F.M. Kirby Neurobiology Center Children’s Hospital, Boston and Dept.of Neurobiology Harvard Medical School CLSB 12-130, 3 Blackfan Street, Boston, MA 02115 Tel:(617)-919-2219 (office) or (617)-919-2264 (lab) Interesting, right? Share with your friends & followers / Intéressant, non? Partagez avec vos amis:

Elucidating mechanisms underlying motor coordination rescue in a mouse model of ARSACS – Dr. Alanna Watt and Dr. Anne McKinney.

In Research in 2017 by ARSACS

The McKinney and Watt labs, which are located in close proximity in the Bellini Life Sciences Complex and who already share a mouse colony of ARSACS mice (Sacs-/-) will determine the physiological mode of action of TPS-100 a pharma and aminopyridines on Purkinje cell function, including synaptic input and output. They will work closely together, to elucidate the mechanism of …

Mapping drug-Sacsin interactions and mitochondrial assemblies in ARSACS patient fibroblasts – Dr.Mohan Babu

In Research in 2017 by ARSACS

Aim 1- Mapping GI network of ARSACS-associated SACS target using CRISPR 1.1. Quantitative readout for scoring GIs 1.2. GI validation and benchmarking Aim 2 – Characterizing ARSACS-linked SACS pathways for function discovery Duration: one year Grant: $69,500 Contact: Dr.Mohan Babu, Asst. Professor CIHR New Investigator,Department of Biochemistry University of Regina Saskatchewan SK S4S 0A2 Tel:(306)-585-4192; Email: mohan.babu@uregina.ca Interesting, right? Share …