Dr. Paul Chapple

“Disrupted Protein Homeostasis in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay””- Dr. Paul Chapple

In Recherche 2017 by ARSACS

1. Identify the proteostasis systems that are activated in sacsin null cells

2. Identify proteins that are recruited to the aggresome-like structure in sacsin null cells

3. Identify if there is evidence for disruption of proteostasis systems in human ARSACS neurons.


Dr. Paul Chapple

Dr. Paul Chapple



Duration:  Second year of a three year project
Grant: 18,965 Pounds ($32,400CDN) per year

Dr.Paul Chapple, Professor of Molecular Cell Biology
Centre for Endocrinology Barts and The London, Queen Mary’s School of Medicine and Dentistry
1st Floor North ,John Vane Science Building,Charterhouse Square
London, EC1M 6BQ
T: +44 (0) 20 7882 6242
E: j.p.chapple@qmul.ac.uk


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