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The Ataxia Charlevoix-Saguenay Foundation participates in the European Joint Programme on Rare Diseases

In Latest News by ARSACS

The Foundation is proud to announce that it will continue to work with the Canadian Institutes of Health Research and the European Union as part of the European Joint Programme on Rare Diseases 2020. The Foundation will fund $225,000 over a 3-year period for projects on Ataxia Charlevoix-Saguenay.  The Canadian investment  will be used to fund the participation of Canadian …

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A great success ! $1.4 Million raised to continue research on Ataxia of Charlevoix-Saguenay

In News Archives by ARSACS

A great success ! $1.4 million net raised for research for Ataxia of Charlevoix-Saguenay at the 13th edition of the Diner des Producteurs . 357 guests attended the annual fundraising event held in Montreal on November 7, 2019. “On behalf of the persons affected with ARSACS and their families, I thank you for your great collective contribution” Jean Groleau, co-founder …

Targeting deregulated calcium homeostasis as potential therapeutic option for ARSACS -Dr. Francesca Maltecca

In Current Research, Research in 2019 by ARSACS

The major aims of this project are: 1) to evaluate the functional role of sacsin at the synaptic level, in particular its involvement in the control of calcium fluxes in Purkinje neurons at the postsynaptic space; 2) to strengthen the evidence of efficacy of an off-label drug regulating calcium homeostasis in ARSACS, by conducting a preclinical trial at post- symptomatic …

Is SARM1 a therapeutic target for ARSACS?- Dr. Thomas Schwarz

In Current Research, Research in 2019 by ARSACS

This project uses the sacsin mutant mouse and mice lacking SARM1 to ask whether the progression of the cell loss in ARSACS can be slowed or prevented by removing SARM1. A positive outcome would make ARSACS a strong candidate for this therapeutic strategy. Duration : 18 months Grant: $144,689 Contact: Dr. Thomas L. Schwarz, Professor, F.M. Kirby Neurobiology Center Children’s …

Towards the Structural Determination of Sacsin- Dr. Walid A. Houry

In Current Research, Research in 2019 by ARSACS

Aim 1. Engineering cells with tagged SACS for purification Aim 2. Purification and determination of SACS structure Aim3: To purify and determine the structure of Canadian SACS mutants Duration : 2 year project Grant: $74,000 in year 1Contact: Dr. Walid A. Houry, Department of Biochemistry, Faculty of Medicine, University of Toronto 661 University Avenue Mars Centre, West Tower, Room 1612 Toronto, …

Is ARSACS a Tauopathy?- Dr. Paul Chapple

In Current Research, Research in 2019 by ARSACS

The objectives of the project will be published at a later date Duration: 3 year funded project Grant: 32,827 pounds Contact: Dr.Paul Chapple, Professor of Molecular Cell BiologyCentre for Endocrinology Barts and The London, Queen Mary’s School of Medicine and Dentistry1st Floor North ,John Vane Science Building,Charterhouse SquareLondon, EC1M 6BQT: +44 (0) 20 7882 6242E: j.p.chapple@qmul.ac.uk