Phenotyping ARSACS in Vitro Using hiPSCs Reprogrammed from Patients and Differentiated into Motor Neurons and Schwabb cells – Dr. François Berthod

In Research in 2018 by ARSACS

The objectives are to: (1) develop and characterize a 3D in vitro human model constituted of fibroblasts, motor
neurons, Schwann cells and myoblasts that recapitulate the ARSACS phenotype at the motor neuron scale, (2)
determine whether the ARSACS phenotype is homogeneous between different patients in vitro.

Duration: one year
Grant: $80,000

Dr. François Berthod, professor department of Surgery
Faculty of medicine of University Laval
tel: 418-990-8255 x61705; courriel:

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