Recherche 2017

Le ministère de la santé de l’Italie accorde du finacement pour le projet « Insight into new therapeutic preclinical strategies in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay type » présenté par:

Dr. Filippo M. Santorelli

Dr. Filippo M. Santorelli, Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa.

Dr. Francesca Maltecca

Dr. Francesca Maltecca, Neurogenomics Unit, Ospedale San Raffaele, Milan, Italy

Dr. Gianni Ciofani, Smart Bio-Interfaces, Istituto Italiano di Tecnologia (IIT), Pontedera (PI)

Résumé du projet :

« Autosomal recessive spastic-ataxia of Charlevoix-Saguenay (ARSACS) is a multisystem hereditary ataxia associated with mutations in SACS, encoding sacsin, a protein whose function is only in part understood. Mutations in SACS impair chaperone-mediated protein-folding activity and mitochondrial(mt) dynamics in Sacs knock-out (KO) mice and human ARSACS cells. Our challenge is to find tools capable to reverse sacsin defects in mice and to identify biomarkers of efficacy in clinical trials. We will use a dual approach: we will analyze mt functionality in Purkinje cells needed to fine tuning new treatment opportunities in Sacs KO mice and will seek for prognostic/predictive biomarkers in patients in order to design new intervention strategies aimed at overcoming brain alterations. To cope with brain alterations in ARSACS and in similar neurological conditions with altered mt functionality, we will also test new nanovectors to easy drug delivery in mutant cells. »

 

Project description to come

Duration: one year
Grant: $100,000
Contacts:

Dr. Bernard Brais

Dr. Bernard Brais

Dr. Bernard Brais, co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital
3801 University Street Montreal, Quebec, Canada H3A 2B4
Tel:(514)-398-3334; Email: bernard.brais@mcgill.ca

Dr Eric Shoubridge

Dr Eric Shoubridge

Dr. Eric Shoubridge, Montreal Neurological Institute and Hospital
3801 University Street Montreal, Quebec, Canada H3A 2B4
Tel: (514)-398-1997; Email: eric.shoubridge@mcgill.ca

Project description to come

 

Duration : One year
Grant: $100,000
Contacts:

Dr. Bernard Brais

Dr. Bernard Brais

Dr. Bernard Brais, co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital
3801 University Street Montreal, Quebec, Canada H3A 2B4
Tel:(514)-398-3334; Email: bernard.brais@mcgill.ca

 

 

 

 

 

 

Dr.Michel Bouuvier, Institute for Research in Immunology and Cancer  (IRIC)

Université de Montréal | Pavillon Marcelle-Coutu | local 1306-5
Tel: (514)-343-6111 poste 0914 ; Email:  www.iric.ca

Project description to come.

Duration: one year
Grant: $98,350
Contact:

Dr Kalle Gehring

Dr Kalle Gehring

Dr. Kalle Gehring, Professor Department of Biochemistry MCGill University
Francesco Bellini Life Sciences Building, 3649 promenade Sir-William-Osler, Office: Room 469; Lab: Room 473, Montreal, Quebec H3G 0B1
Tel:(514)-398-7287; Lab: (514)-398-2873/1496; Fax:(514)-398-2983; Email: kalle.gehring@mcgill.ca

Caractériser les déficiences de force et de contrôle de mouvements volontaires et les limitations d’activité liées à la mobilité; 2) caractériser leurs interrelations; et 3) identifier les variables cliniques qui expliquent le mieux les limitations d’activités telle que la vitesse de marche.

Dr. Luc J. Hébert

Dr. Luc J. Hébert

 

Durée: un an
Bourse : $73,300

Contact:

Dr.Luc Hébert , Chercheur, CIRRIS,

Bureau H-1702 . IRDPQ, 525 boulevard Hamel, Québec QC  G1M 2S8

Téléphone: 418-529-9141 poste 6579