Therapeutic Approaches for ARSACS- Dr. Benoit Gentil and Dr. Heather Durham

In Current Research by ARSACS

The current proposal proposes to capitalize on our discoveries and to move forward in two
directions. First, pursue the protein/gene replacement approach until it produces a preclinical proof of
concept that includes a translatable delivery method. Second, assess the therapeutic potential of HDAC
inhibitors for ARSACS. Although not included as a specific aim in this proposal, developments with
HSP inducers in the ALS study will be applied in the ARSACS models.

Duration: One year
Grant: $80,000

Contacts

DR. Benoit Gentil
Room 649, Montreal Neurological Institute
3801 University street, Montreal, H3A 2B4
Tel: 514-398-8509; Fax: 514-398-1509; email: benoit.gentil@mcgill.ca

Dr. Heather Durham
Room 649, Montreal Neurological Institute
3801 University street, Montreal, H3A 2B4
Tel: 514-398-8509; Fax: 514-398-1509; email: heather.durham@mcgill.ca

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