The Houry group is interested in characterizing the structure and function of Sacsin. To this end, the group has generated a cell line expressing endogenously tagged SACS gene. This will be used as a tool to study the localization of the protein under different growth and stress conditions as well as for other cell biological studies. Furthermore, the cell line will allow for the purification of the tagged protein and its subsequent biochemical and structural characterization.
Duration : 2nd year of the project
Dr. Walid A. Houry, Department of Biochemistry Faculty of Medicine, University of Toronto
661 University Avenue,Mars Centre, West Tower, Room 1612, Toronto, ON Canada M5G 1M1
Tel: 416 946 7141; Fax: 416 978 8548